Term Information

Accession
GO:0086095
Name
positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
Ontology
biological_process
Synonyms
muscarinic receptor signaling pathway involved in activation of IKACH, positive regulation of IKACh channel activity by G-protein coupled acetylcholine receptor signaling, Gbeta/gamma-coupled muscarinic receptor signaling pathway involved in negative regulation of heart rate, cardiac muscarinic receptor signaling via Gbeta/gamma, muscarinic receptor signaling pathway involved in ion channel activation
Alternate IDs
None
Definition
A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G protein-coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate. Source: GOC:BHF, Wikipedia:G_protein-gated_ion_channel, GOC:mtg_cardiac_conduct_nov11
Comment
None
History
See term history for GO:0086095 at QuickGO
Subset
gocheck_do_not_annotate
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086095)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate [is_a relation] is_a  G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086033)
positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate [is_a relation] is_a  positive regulation of G-protein activated inward rectifier potassium channel activity (GO:1900129)
positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate [RO:0002213 relation] RO:0002213  G-protein activated inward rectifier potassium channel activity (GO:0015467)

This term has no children.

None.