Term Information

Accession
GO:0086033
Name
G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
Ontology
biological_process
Synonyms
G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate, M2 receptor signalling pathway involved in negative regulation of heart rate, muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate, muscarinic receptor signalling pathway involved in negative regulation of heart rate
Alternate IDs
None
Definition
A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate. Source: GOC:BHF, Wikipedia:G_protein-gated_ion_channel, GOC:mtg_cardiac_conduct_nov11
Comment
None
History
See term history for GO:0086033 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086033)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate [BFO:0000050 relation] BFO:0000050  negative regulation of heart rate (GO:0010459)
G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate [BFO:0000050 relation] BFO:0000050  negative regulation of heart rate by acetylcholine (GO:0003063)
G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate [is_a relation] is_a  G protein-coupled acetylcholine receptor signaling pathway involved in heart process (GO:0086093)
Children of G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086033)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086095) [is_a relation] is_a  G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086102) [is_a relation] is_a  G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
None.