Term Information

Accession
GO:0005242
Name
inward rectifier potassium channel activity
Ontology
molecular_function
Synonyms
Kir channel activity
Alternate IDs
None
Definition
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. Source: GOC:cb, PMID:14977398, GOC:mah
Comment
None
History
See term history for GO:0005242 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of inward rectifier potassium channel activity (GO:0005242)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
inward rectifier potassium channel activity [is_a relation] is_a  voltage-gated potassium channel activity (GO:0005249)
inward rectifier potassium channel activity [is_a relation] is_a  ligand-gated monoatomic cation channel activity (GO:0099094)
Children of inward rectifier potassium channel activity (GO:0005242)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of inward rectifier potassium channel activity (GO:1901980) [RO:0002213 relation] RO:0002213  inward rectifier potassium channel activity
regulation of inward rectifier potassium channel activity (GO:1901979) [RO:0002211 relation] RO:0002211  inward rectifier potassium channel activity
G-protein activated inward rectifier potassium channel activity (GO:0015467) [is_a relation] is_a  inward rectifier potassium channel activity
ATP-activated inward rectifier potassium channel activity (GO:0015272) [is_a relation] is_a  inward rectifier potassium channel activity
negative regulation of inward rectifier potassium channel activity (GO:1903609) [RO:0002212 relation] RO:0002212  inward rectifier potassium channel activity