extrinsic apoptotic pathway, extrinsic apoptotic signalling pathway, death receptor-mediated apoptosis, extrinsic apoptosis, extrinsic apoptotic signaling pathway in presence of ligand
Alternate IDs
None
Definition
The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
Source:
GOC:yaf,
GOC:mtg_apoptosis,
PMID:17340152
Comment
Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer.