Term Information

Accession
GO:0097192
Name
extrinsic apoptotic signaling pathway in absence of ligand
Ontology
biological_process
Synonyms
extrinsic apoptotic signalling pathway in absence of ligand, dependence receptor signaling pathway, extrinsic apoptosis in absence of ligand
Alternate IDs
None
Definition
The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. Source: PMID:20816705, PMID:15044679, GOC:mtg_apoptosis
Comment
For dependence receptors, absence of a ligand or withdrawal of a ligand from a receptor acts as a signal. An example of 'extrinsic apoptotic signaling pathway in absence of ligand' is withdrawal of a growth factor such as NGF, even if traditionally apoptosis induced via growth factor withdrawal has been classified as an instance of intrinsic apoptosis. See an example in PMID:19767770. Ligands whose withdrawal or absence induce apoptosis should be annotated to GO:2001239 'regulation of extrinsic apoptotic signaling pathway in absence of ligand', rather than to the pathway term itself. Examples of gene products that may be annotated to GO:0097192 'extrinsic apoptotic signaling pathway in absence of ligand' include dependence receptors such as DCC or UNC5B, which relay lethal signals in the absence of their ligand (netrin-1). In the case of DCC and UNC5B, the signaling proceeds through the assembly of a DRAL- and TUCAN- (or NLRP1-) containing caspase-9-activating complex or by the dephosphorylation-mediated activation of death-associated protein kinase 1 (DAPK1) by UNC5B-bound protein phosphatase 2A (PP2A), respectively. DAPK1 can mediate the direct activation of executioner caspases or favor MOMP (reviewed in PMID:21760595). Also see PMID:21172653 (annotations to UNC5B and PR65beta, UniProt symbols O08722, PPP2R1B and P30154).
History
See term history for GO:0097192 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
extrinsic apoptotic signaling pathway in absence of ligand [is_a relation] is_a  extrinsic apoptotic signaling pathway (GO:0097191)
extrinsic apoptotic signaling pathway in absence of ligand [is_a relation] is_a  signal transduction in absence of ligand (GO:0038034)
Children of extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241) [RO:0002213 relation] RO:0002213  extrinsic apoptotic signaling pathway in absence of ligand
regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001239) [RO:0002211 relation] RO:0002211  extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001240) [RO:0002212 relation] RO:0002212  extrinsic apoptotic signaling pathway in absence of ligand
None.