Planteome: Term Details for "extrinsic apoptotic signaling pathway via death domain receptors" (GO:0008625)

Notice

Some functionality on this page depends on JavaScript. To fully use the features of AmiGO 2, enable JavaScript in your browser and reload from the landing page.

Term Information

Accession: GO:0008625
Name: extrinsic apoptotic signaling pathway via death domain receptors
Ontology: biological_process
Synonyms: induction of apoptosis via death receptors, induction of apoptosis via death domain receptors, death receptor-mediated apoptosis
Alternate IDs: None
Definition: The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. Source: GOC:mah, GOC:mtg_apoptosis
Comment: Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013.
History: See term history for GO:0008625 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to extrinsic apoptotic signaling pathway via death domain receptors.; Link to all direct and indirect annotations to extrinsic apoptotic signaling pathway via death domain receptors.; Link to all direct and indirect annotations download (limited to first 10,000) for extrinsic apoptotic signaling pathway via death domain receptors.
Feedback: Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Viewing options

BFO:0000001 entity
BFO:0000003 occurrent
GO:0008150 biological_process
GO:0065007 biological regulation
GO:0009987 cellular process
BFO:0000015 process
GO:0008219 cell death
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0012501 programmed cell death
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0097190 apoptotic signaling pathway
GO:0007166 cell surface receptor signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0036462 TRAIL-activated apoptotic signaling pathway

Parents of extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)

subject	relation	object
extrinsic apoptotic signaling pathway via death domain receptors	is_a	extrinsic apoptotic signaling pathway (GO:0097191)

Children of extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)

subject	relation	object
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)	RO:0002212	extrinsic apoptotic signaling pathway via death domain receptors
regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041)	RO:0002211	extrinsic apoptotic signaling pathway via death domain receptors
TRAIL-activated apoptotic signaling pathway (GO:0036462)	is_a	extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	RO:0002213	extrinsic apoptotic signaling pathway via death domain receptors

extrinsic apoptotic signaling pathway via death domain receptors

Term Information

Filter results

Viewing options

Parents of extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)

Children of extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)

None.