Planteome logo

polymeric IgA immunoglobulin complex

Term Information

Accession
GO:0071749
Name
polymeric IgA immunoglobulin complex
Ontology
cellular_component
Synonyms
pIgA antibody, polymeric IgA antibody, pIgA1 antibody, polymeric IgA1 antibody
Alternate IDs
None
Definition
A protein complex composed of two, three, or four monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. Source: ISBN:0781765196, PMID:16362985, GOC:add
Comment
Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a polymeric forms.
History
See term history for GO:0071749 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of polymeric IgA immunoglobulin complex (GO:0071749)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
polymeric IgA immunoglobulin complex [is_a relation] is_a  IgA immunoglobulin complex, circulating (GO:0071746)
Children of polymeric IgA immunoglobulin complex (GO:0071749)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
secretory IgA immunoglobulin complex (GO:0071751) [is_a relation] is_a  polymeric IgA immunoglobulin complex
dimeric IgA immunoglobulin complex (GO:0071750) [is_a relation] is_a  polymeric IgA immunoglobulin complex
None.