Term Information

Accession
GO:0086024
Name
adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate
Ontology
biological_process
Synonyms
Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate, If activation by beta-adrenergic receptor signaling pathway, activation of funny current by beta-adrenergic receptor signaling pathway, adenylate cyclase-activating cardiac adrenergic receptor signaling pathway, beta adrenergic receptor signaling pathway involved in positive regulation of heart rate, adrenergic receptor signaling pathway involved in positive regulation of heart rate, adrenergic receptor signalling pathway involved in positive regulation of heart rate
Alternate IDs
None
Definition
An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of heart contraction. Binding of adrenalin or noradrenalin to a beta-adrenergic receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gs protein. Gs activates adenylate cyclase to increase intracellular cyclic-AMP (cAMP) levels. cAMP binds directly to F-channels to allow an inward flow of sodium (known as funny current, or If current). The funny current is responsible for membrane depolarization and an increase in heart rate. Source: GOC:BHF, GOC:bf, PMID:21099118, GOC:mtg_cardiac_conduct_nov11
Comment
None
History
See term history for GO:0086024 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate (GO:0086024)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate [is_a relation] is_a  positive regulation of heart rate by epinephrine-norepinephrine (GO:0001996)
adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate [BFO:0000050 relation] BFO:0000050  positive regulation of heart rate (GO:0010460)
adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate [is_a relation] is_a  adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate (GO:0140200)

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None.