Term Information

Accession
GO:0070782
Name
phosphatidylserine exposure on apoptotic cell surface
Ontology
biological_process
Synonyms
externalization of phosphatidylserine
Alternate IDs
None
Definition
A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity. Source: PMID:11536005, GOC:mah, GOC:mtg_apoptosis, GOC:rk
Comment
In normal cells, phosphatidylserine residues are found exclusively on the inner side of the cellular membrane. During apoptosis, phosphatidylserine is transported to the outer cell surface by scramblase proteins. This event acts as an "eat-me" signal for macrophages to dispose of the dying cell. When annotating to this term, curators should be aware of the following: 1) phosphatidylserine exposure on the cell surface can occur in circumstances other than apoptosis (for example, when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system, see PMID:21107324). Do not annotate to GO:0070782 unless phosphatidylserine exposure is shown to be part of an apoptotic event. 2) Caution should be applied when a study quotes annexin V assays. The annexin A5 protein binds to phosphatidylserine-containing membrane surfaces, which are usually only present on the inner leaflet of the membrane. However, in cells undergoing apoptosis, phosphatidylserine becomes exposed on the outer leaflet of the membrane. A positive annexin assay can therefore be linked to apoptotic death, but it shouldn't be confused with molecular events strictly involved in the process of phosphatidylserine exposure.
History
See term history for GO:0070782 at QuickGO
Subset
None
Feedback
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Parents of phosphatidylserine exposure on apoptotic cell surface (GO:0070782)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
phosphatidylserine exposure on apoptotic cell surface [is_a relation] is_a  plasma membrane phospholipid scrambling (GO:0017121)
phosphatidylserine exposure on apoptotic cell surface [BFO:0000050 relation] BFO:0000050  execution phase of apoptosis (GO:0097194)
phosphatidylserine exposure on apoptotic cell surface [BFO:0000051 relation] BFO:0000051  phospholipid scramblase activity (GO:0017128)
Children of phosphatidylserine exposure on apoptotic cell surface (GO:0070782)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of phosphatidylserine exposure on apoptotic cell surface (GO:1905782) [RO:0002213 relation] RO:0002213  phosphatidylserine exposure on apoptotic cell surface
regulation of phosphatidylserine exposure on apoptotic cell surface (GO:1905780) [RO:0002211 relation] RO:0002211  phosphatidylserine exposure on apoptotic cell surface
negative regulation of phosphatidylserine exposure on apoptotic cell surface (GO:1905781) [RO:0002212 relation] RO:0002212  phosphatidylserine exposure on apoptotic cell surface
None.