Term Information

Accession
GO:0040033
Name
sRNA-mediated gene silencing
Ontology
biological_process
Synonyms
small RNA-mediated gene silencing, RNA-mediated gene silencing by inhibition of translation, downregulation of mRNA translation, ncRNA-mediated, inhibition of mRNA translation, ncRNA-mediated
Alternate IDs
None
Definition
A post-transcriptional gene silencing pathway mediated by the action of small regulatory non-coding RNAs (sRNAs). sRNAs are 20-500 nucleotides in length and found in bacteria. Source: PMID:2468565, PMID:33963446, PMID:12460531
Comment
It is postulated that there 3 mechanisms of sRNA-mediated gene silencing: (i) translation inhibition, (ii) RNA destabilization, and (iii) transcription termination loop formation (as this is common when looking at riboswitches). sRNA mediated gene silencing is sometimes referred to as 'regulation of riboswitch'.
History
See term history for GO:0040033 at QuickGO
Subset
prokaryote_subset
Feedback
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Parents of sRNA-mediated gene silencing (GO:0040033)
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sRNA-mediated gene silencing [is_a relation] is_a  regulatory ncRNA-mediated post-transcriptional gene silencing (GO:0035194)

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