Term Information

Accession
GO:0038014
Name
negative regulation of insulin receptor signaling pathway by insulin receptor internalization
Ontology
biological_process
Synonyms
negative regulation of insulin receptor signalling pathway by insulin receptor internalization, agonist-stimulated insulin receptor internalization
Alternate IDs
None
Definition
Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation. Source: GOC:signaling, PMID:7821727, PMID:18492485, PMID:9609114, GOC:bf, PMID:7978876
Comment
None
History
See term history for GO:0038014 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of negative regulation of insulin receptor signaling pathway by insulin receptor internalization (GO:0038014)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of insulin receptor signaling pathway by insulin receptor internalization [RO:0002212 relation] RO:0002212  insulin receptor signaling pathway (GO:0008286)
negative regulation of insulin receptor signaling pathway by insulin receptor internalization [is_a relation] is_a  negative regulation of signal transduction by receptor internalization (GO:0038011)
negative regulation of insulin receptor signaling pathway by insulin receptor internalization [is_a relation] is_a  insulin receptor internalization (GO:0038016)
negative regulation of insulin receptor signaling pathway by insulin receptor internalization [is_a relation] is_a  negative regulation of insulin receptor signaling pathway (GO:0046627)

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None.