Term Information

Accession
GO:0036378
Name
calcitriol biosynthetic process from calciol
Ontology
biological_process
Synonyms
calcitriol biosynthesis from calciol, vitamin D3 activation, 1alpha,25(OH)2D3 biosynthesis, 1alpha,25-dihydroxycholecalciferol biosynthesis, 1alpha,25-dihydroxyvitamin D3 biosynthesis
Alternate IDs
None
Definition
Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol. Source: GOC:BHF, PMID:17426122, PMID:20511049, GOC:rl
Comment
None
History
See term history for GO:0036378 at QuickGO
Subset
None
Feedback
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of calcitriol biosynthetic process from calciol (GO:0036378)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
calcitriol biosynthetic process from calciol [is_a relation] is_a  polyol biosynthetic process (GO:0046173)
calcitriol biosynthetic process from calciol [is_a relation] is_a  vitamin D biosynthetic process (GO:0042368)
calcitriol biosynthetic process from calciol [is_a relation] is_a  vitamin D3 metabolic process (GO:0070640)
calcitriol biosynthetic process from calciol [is_a relation] is_a  cellular alcohol biosynthetic process (GO:0044108)
Children of calcitriol biosynthetic process from calciol (GO:0036378)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
calcidiol 1-monooxygenase activity (GO:0004498) [BFO:0000050 relation] BFO:0000050  calcitriol biosynthetic process from calciol
vitamin D3 25-hydroxylase activity (GO:0030343) [BFO:0000050 relation] BFO:0000050  calcitriol biosynthetic process from calciol
None.