Term Information

Accession
GO:0004498
Name
calcidiol 1-monooxygenase activity
Ontology
molecular_function
Synonyms
25-hydroxy vitamin D3 1-alpha-hydroxylase activity, 25-hydroxycholecalciferol 1-hydroxylase activity, calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating), 1-hydroxylase-25-hydroxyvitamin D3 activity, 25-OHD-1 alpha-hydroxylase activity, 25-hydroxy D3-1alpha-hydroxylase activity, 25-hydroxycholecalciferol 1-monooxygenase activity, 25-hydroxycholecalciferol 1alpha-hydroxylase activity, 25-hydroxycholecalciferol-1-hydroxylase activity, 25-hydroxyvitamin D-1 alpha hydroxylase activity, 25-hydroxyvitamin D3 1alpha-hydroxylase activity, cytochrome P450 CYP27B
Alternate IDs
None
Definition
Catalysis of the reaction: calcidiol + H+ + NADPH + O2 = calcitriol + H2O + NADP+. Source: RHEA:20573, EC:1.14.15.18
Comment
None
History
See term history for GO:0004498 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of calcidiol 1-monooxygenase activity (GO:0004498)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
calcidiol 1-monooxygenase activity [is_a relation] is_a  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709)
calcidiol 1-monooxygenase activity [BFO:0000050 relation] BFO:0000050  calcitriol biosynthetic process from calciol (GO:0036378)
Children of calcidiol 1-monooxygenase activity (GO:0004498)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of calcidiol 1-monooxygenase activity (GO:0060559) [RO:0002213 relation] RO:0002213  calcidiol 1-monooxygenase activity
regulation of calcidiol 1-monooxygenase activity (GO:0060558) [RO:0002211 relation] RO:0002211  calcidiol 1-monooxygenase activity
negative regulation of calcidiol 1-monooxygenase activity (GO:0010956) [RO:0002212 relation] RO:0002212  calcidiol 1-monooxygenase activity