Term Information

Accession
GO:0035195
Name
miRNA-mediated gene silencing
Ontology
biological_process
Synonyms
gene silencing by miRNA, gene silencing by microRNA, microRNA-mediated gene silencing
Alternate IDs
None
Definition
A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants. Source: PMID:28379604, PMID:23985560, GOC:bc, PMID:15066283, PMID:14744438, GOC:aruk, PMID:15066275, GOC:rl, PMID:23209154
Comment
None
History
See term history for GO:0035195 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of miRNA-mediated gene silencing (GO:0035195)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
miRNA-mediated gene silencing [is_a relation] is_a  regulatory ncRNA-mediated post-transcriptional gene silencing (GO:0035194)
Children of miRNA-mediated gene silencing (GO:0035195)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of miRNA-mediated gene silencing (GO:2000637) [RO:0002213 relation] RO:0002213  miRNA-mediated gene silencing
negative regulation of miRNA-mediated gene silencing (GO:0060965) [RO:0002212 relation] RO:0002212  miRNA-mediated gene silencing
pre-miRNA export from nucleus (GO:0035281) [BFO:0000050 relation] BFO:0000050  miRNA-mediated gene silencing
miRNA-mediated gene silencing by mRNA destabilization (GO:0035279) [is_a relation] is_a  miRNA-mediated gene silencing
regulation of miRNA-mediated gene silencing (GO:0060964) [RO:0002211 relation] RO:0002211  miRNA-mediated gene silencing
miRNA-mediated gene silencing by inhibition of translation (GO:0035278) [is_a relation] is_a  miRNA-mediated gene silencing
None.