Term Information

Accession
GO:0019005
Name
SCF ubiquitin ligase complex
Ontology
cellular_component
Synonyms
CDL1 complex, CRL1 complex, Cul1-RING ubiquitin ligase complex, SCF complex, Skp1/Cul1/F-box protein complex, cullin-RING ligase 1, SCF complex substrate recognition subunit
Alternate IDs
None
Definition
A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). Source: PMID:15688063, PMID:15571813
Comment
None
History
See term history for GO:0019005 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of SCF ubiquitin ligase complex (GO:0019005)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
SCF ubiquitin ligase complex [is_a relation] is_a  cullin-RING ubiquitin ligase complex (GO:0031461)
Children of SCF ubiquitin ligase complex (GO:0019005)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
SCF-Dia2/Pof3 ubiquitin ligase complex (GO:0097663) [is_a relation] is_a  SCF ubiquitin ligase complex
SCF-Das1 ubiquitin ligase complex (GO:0097662) [is_a relation] is_a  SCF ubiquitin ligase complex
nuclear SCF ubiquitin ligase complex (GO:0043224) [is_a relation] is_a  SCF ubiquitin ligase complex
SCF-Skp2 ubiquitin ligase complex (GO:0097669) [is_a relation] is_a  SCF ubiquitin ligase complex
SCF-Saf1/Pof9 ubiquitin ligase complex (GO:0097668) [is_a relation] is_a  SCF ubiquitin ligase complex
SCF-Cdc4 ubiquitin ligase complex (GO:0097660) [is_a relation] is_a  SCF ubiquitin ligase complex
SCF-Mdm30 ubiquitin ligase complex (GO:0097665) [is_a relation] is_a  SCF ubiquitin ligase complex
cytoplasmic SCF ubiquitin ligase complex (GO:0043223) [is_a relation] is_a  SCF ubiquitin ligase complex
SCF-Ctf13 ubiquitin ligase complex (GO:0097661) [is_a relation] is_a  SCF ubiquitin ligase complex
SCF-Grr1/Pof2 ubiquitin ligase complex (GO:0097664) [is_a relation] is_a  SCF ubiquitin ligase complex
SCF-Rcy1/Pof6 ubiquitin ligase complex (GO:0097667) [is_a relation] is_a  SCF ubiquitin ligase complex
SCF-YDR131C ubiquitin ligase complex (GO:0097671) [is_a relation] is_a  SCF ubiquitin ligase complex
SCF-Hrt3/Pof7 ubiquitin ligase complex (GO:0097675) [is_a relation] is_a  SCF ubiquitin ligase complex
SCF-Ufo1/Pof10 ubiquitin ligase complex (GO:0097670) [is_a relation] is_a  SCF ubiquitin ligase complex
SCF-YLR352W ubiquitin ligase complex (GO:0097674) [is_a relation] is_a  SCF ubiquitin ligase complex
SCF-Met30/Pof1 ubiquitin ligase complex (GO:0097666) [is_a relation] is_a  SCF ubiquitin ligase complex
SCF-Pof5 ubiquitin ligase complex (GO:0097672) [is_a relation] is_a  SCF ubiquitin ligase complex
SCF-Ucc1 ubiquitin ligase complex (GO:0097673) [is_a relation] is_a  SCF ubiquitin ligase complex
Wikipedia
SCF_complex