Term Information

Accession
GO:0003713
Name
transcription coactivator activity
Ontology
molecular_function
Synonyms
transcription co-activator activity, RNA polymerase II transcription co-activator activity, RNA polymerase II transcription coactivator activity, RNA polymerase II transcription mediator activity
Alternate IDs
GO:0001105
Definition
A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. Source: GOC:txnOH-2018, PMID:10213677, PMID:16858867
Comment
For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.
History
See term history for GO:0003713 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of transcription coactivator activity (GO:0003713)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
transcription coactivator activity [BFO:0000050 relation] BFO:0000050  positive regulation of DNA-templated transcription (GO:0045893)
transcription coactivator activity [is_a relation] is_a  transcription coregulator activity (GO:0003712)
Children of transcription coactivator activity (GO:0003713)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
nuclear receptor coactivator activity (GO:0030374) [is_a relation] is_a  transcription coactivator activity
None.