Term Information

Accession
GO:0000184
Name
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Ontology
biological_process
Synonyms
mRNA breakdown, nonsense-mediated decay, mRNA catabolic process, nonsense-mediated, mRNA catabolism, nonsense-mediated, mRNA degradation, nonsense-mediated decay, nonsense-mediated mRNA decay, nuclear mRNA catabolic process, nonsense-mediated decay
Alternate IDs
None
Definition
The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. Source: GOC:krc, PMID:10025395, GOC:ma
Comment
None
History
See term history for GO:0000184 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [is_a relation] is_a  nuclear-transcribed mRNA catabolic process (GO:0000956)
Children of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:2000622) [RO:0002211 relation] RO:0002211  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:2000623) [RO:0002212 relation] RO:0002212  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay (GO:0070478) [is_a relation] is_a  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:2000624) [RO:0002213 relation] RO:0002213  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay (GO:0070479) [is_a relation] is_a  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay