Planteome: Term Details for "Wnt signalosome" (GO:1990909)

Accession: GO:1990909
Name: Wnt signalosome
Ontology: cellular_component
Synonyms: LRP5/6 signalosome, Wnt signalosome complex, Wnt-LRP5/6 signalosome, LRP6 signalosome
Alternate IDs: None
Definition: A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. Source: PMID:22899650, GOC:PARL, PMID:25336320, GOC:bf
Comment: Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription.
History: See term history for GO:1990909 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to Wnt signalosome.; Link to all direct and indirect annotations to Wnt signalosome.; Link to all direct and indirect annotations download (limited to first 10,000) for Wnt signalosome.
Feedback: Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

subject	relation	object
Wnt signalosome	is_a	protein-containing complex (GO:0032991)
Wnt signalosome	BFO:0000051	Wnt-Frizzled-LRP5/6 complex (GO:1990851)

This term has no children.

Wnt signalosome