Term Information

Accession
GO:1990728
Name
mitotic spindle assembly checkpoint MAD1-MAD2 complex
Ontology
cellular_component
Synonyms
MAD1-MAD2 complex
Alternate IDs
None
Definition
A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex. Source: PMID:22898774, PMID:12006501, GOC:bhm
Comment
An example of this is MAD1 in human (Q9Y6D9) in PMID:12006501 (inferred from physical interaction).
History
See term history for GO:1990728 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of mitotic spindle assembly checkpoint MAD1-MAD2 complex (GO:1990728)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
mitotic spindle assembly checkpoint MAD1-MAD2 complex [is_a relation] is_a  protein-containing complex (GO:0032991)
mitotic spindle assembly checkpoint MAD1-MAD2 complex [BFO:0000051 relation] BFO:0000051  MAD1 complex (GO:1990706)
mitotic spindle assembly checkpoint MAD1-MAD2 complex [BFO:0000050 relation] BFO:0000050  cytoplasm (GO:0005737)

This term has no children.

None.