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mitotic spindle assembly checkpoint MAD1-MAD2 complex

Term Information

Accession
GO:1990728
Name
mitotic spindle assembly checkpoint MAD1-MAD2 complex
Ontology
cellular_component
Synonyms
MAD1-MAD2 complex
Alternate IDs
None
Definition
A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex. Source: PMID:22898774, PMID:12006501, GOC:bhm
Comment
An example of this is MAD1 in human (Q9Y6D9) in PMID:12006501 (inferred from physical interaction).
History
See term history for GO:1990728 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of mitotic spindle assembly checkpoint MAD1-MAD2 complex (GO:1990728)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
mitotic spindle assembly checkpoint MAD1-MAD2 complex [is_a relation] is_a  protein-containing complex (GO:0032991)
mitotic spindle assembly checkpoint MAD1-MAD2 complex [BFO:0000051 relation] BFO:0000051  MAD1 complex (GO:1990706)
mitotic spindle assembly checkpoint MAD1-MAD2 complex [BFO:0000050 relation] BFO:0000050  cytoplasm (GO:0005737)

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None.