Planteome: Term Details for "calprotectin complex" (GO:1990660)

Accession: GO:1990660
Name: calprotectin complex
Ontology: cellular_component
Synonyms: calprotectin heterodimer
Alternate IDs: None
Definition: A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Source: PMID:25417112, GOC:bhm
Comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay).
History: See term history for GO:1990660 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to calprotectin complex.; Link to all direct and indirect annotations to calprotectin complex.; Link to all direct and indirect annotations download (limited to first 10,000) for calprotectin complex.
Feedback: Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

subject	relation	object
calprotectin complex	is_a	protein-containing complex (GO:0032991)

This term has no children.

calprotectin complex