Planteome: Term Details for "ANPR-A receptor complex" (GO:1990620)

Accession: GO:1990620
Name: ANPR-A receptor complex
Ontology: cellular_component
Synonyms: NPR1 receptor complex
Alternate IDs: None
Definition: A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure. Source: GOC:ame, PMID:15117952
Comment: An example of this is Npr1 in rat (UniProt symbol P18910) in PMID:15117952 (inferred from direct assay).
History: See term history for GO:1990620 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to ANPR-A receptor complex.; Link to all direct and indirect annotations to ANPR-A receptor complex.; Link to all direct and indirect annotations download (limited to first 10,000) for ANPR-A receptor complex.
Feedback: Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

subject	relation	object
ANPR-A receptor complex	is_a	receptor complex (GO:0043235)

This term has no children.

ANPR-A receptor complex