Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms.
Source:PMID:23229515,
GOC:bhm
Comment
An example of this is CLOCK in human (O15516) in PMID:23229515 (inferred from physical interaction).