Term Information

Accession
GO:1990270
Name
platelet-derived growth factor receptor-ligand complex
Ontology
cellular_component
Synonyms
PDGF receptor-ligand complex, PDGF-AA-receptor alpha complex, PDGF-AB-receptor alpha complex, PDGF-AB-receptor beta complex, PDGF-BB-receptor alpha complex, PDGF-BB-receptor alpha-beta complex, PDGF-BB-receptor beta complex, PDGF-CC-receptor alpha complex, PDGF-CC-receptor alpha-beta complex, PDGF-CC-receptor beta complex, PDGF-DD-receptor alpha-beta complex, PDGF-DD-receptor beta complex, PDGF complex, receptor-ligand complex
Alternate IDs
None
Definition
A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes. Source: PMID:11331882, GOC:bhm
Comment
An example of this is PDGFA-PGFRA in human (UniProt symbols P04085, P16234) in PMID:7679113 (inferred from direct assay).
History
See term history for GO:1990270 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of platelet-derived growth factor receptor-ligand complex (GO:1990270)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
platelet-derived growth factor receptor-ligand complex [is_a relation] is_a  plasma membrane protein complex (GO:0098797)
platelet-derived growth factor receptor-ligand complex [BFO:0000051 relation] BFO:0000051  platelet-derived growth factor complex (GO:1990265)
platelet-derived growth factor receptor-ligand complex [BFO:0000051 relation] BFO:0000051  receptor complex (GO:0043235)

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None.