Planteome: Term Details for "non-ribosomal peptide synthetase activity" (GO:1904091)

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Term Information

Accession: GO:1904091
Name: non-ribosomal peptide synthetase activity
Ontology: molecular_function
Synonyms: peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis, peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process, PCP, peptidyl carrier protein, peptidyl carrier protein activity
Alternate IDs: None
Definition: Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization. Source: PMID:10631508, PMID:17502372
Comment: Examples are the ferrichrome synthetase Sib1 in S. pombe and the peptidyl carrier protein (PCP) module in bacterial nonribosomal peptide synthases (NRPSs), which holds the peptidyl group and acts as a swinging arm, limiting diffusion until the peptide comes into contact with the next enzymatic module in the NRPS process.
History: See term history for GO:1904091 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to non-ribosomal peptide synthetase activity.; Link to all direct and indirect annotations to non-ribosomal peptide synthetase activity.; Link to all direct and indirect annotations download (limited to first 10,000) for non-ribosomal peptide synthetase activity.
Feedback: Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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GO:0008150 biological_process
BFO:0000015 process
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0044237 cellular metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0044249 cellular biosynthetic process
GO:0034641 cellular nitrogen compound metabolic process
BFO:0000001 entity
BFO:0000003 occurrent
GO:0071704 organic substance metabolic process
GO:0043603 amide metabolic process
GO:0044271 cellular nitrogen compound biosynthetic process
GO:1901576 organic substance biosynthetic process
GO:1901564 organonitrogen compound metabolic process
GO:0043604 amide biosynthetic process
GO:1901566 organonitrogen compound biosynthetic process
GO:0006518 peptide metabolic process
GO:0003674 molecular_function
GO:0043043 peptide biosynthetic process
GO:0003824 catalytic activity
GO:0019184 nonribosomal peptide biosynthetic process
GO:1904091 non-ribosomal peptide synthetase activity
GO:0097429 amino acid ligation activity by nonribosomal peptide synthase
GO:0004363 glutathione synthase activity

Parents of non-ribosomal peptide synthetase activity (GO:1904091)

subject	relation	object
non-ribosomal peptide synthetase activity	is_a	catalytic activity (GO:0003824)
non-ribosomal peptide synthetase activity	BFO:0000050	nonribosomal peptide biosynthetic process (GO:0019184)

Children of non-ribosomal peptide synthetase activity (GO:1904091)

subject	relation	object
amino acid ligation activity by nonribosomal peptide synthase (GO:0097429)	is_a	non-ribosomal peptide synthetase activity
glutathione synthase activity (GO:0004363)	is_a	non-ribosomal peptide synthetase activity

non-ribosomal peptide synthetase activity

Term Information

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Parents of non-ribosomal peptide synthetase activity (GO:1904091)

Children of non-ribosomal peptide synthetase activity (GO:1904091)

None.