A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and two or more dendritic spines protruding either from a single dendrite or from multiple dendrites.
Source:PMID:11248111,
PMID:7482800,
PMID:10586883,
GOC:bc,
PMID:22028887,
PMID:24487234,
GOC:aruk,
PMID:8366344