Term Information

Accession
GO:0140627
Name
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
Ontology
biological_process
Synonyms
DesCEND
Alternate IDs
None
Definition
The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. Source: PMID:29775578, PMID:29779948
Comment
None
History
See term history for GO:0140627 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (GO:0140627)
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ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [is_a relation] is_a  proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)

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