Term Information

Accession
GO:0140504
Name
microlipophagy
Ontology
biological_process
Synonyms
lipid droplet autophagy
Alternate IDs
None
Definition
Microautophagy-mediated direct internalization of lipid droplets into a lysosome-like vacuole during nutrient depletion, such as during the transition to stationary phase or in response to nutrient limitation. Microlipophagy is mediated by the formation of sterol-enriched vacuolar microdomains at sites of engulfment. Initiation of microautophagy is defined as the point where liquid-ordered microdomains are formed at sites of engulfment, that requires S. cerevisiae Atg32p and Atg21p, as well as Niemann-Pick type C (NPC) sterol transporter proteins, Ncr1p and Npc2p. This is followed by redistribution of Atg14p from ER exit sites onto liquid-ordered vacuole membrane domains through interaction with stabilized AMP-activated protein kinase (AMPK), and together with Atg6p facilities docking and internalization of lipid droplets (LDs) at sites of invagination. Source: PMID:29293450, PMID:25070953, PMID:29601311, PMID:28394250, PMID:28838958
Comment
None
History
See term history for GO:0140504 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of microlipophagy (GO:0140504)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
microlipophagy [is_a relation] is_a  lysosomal microautophagy (GO:0016237)
Children of microlipophagy (GO:0140504)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of microlipophagy (GO:0140505) [RO:0002211 relation] RO:0002211  microlipophagy
None.