Term Information

Accession
GO:0140358
Name
P-type transmembrane transporter activity
Ontology
molecular_function
Synonyms
E1-E2 ATPase, P-type ATPase
Alternate IDs
None
Definition
Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. Source: PMID:18075584, PMID:25918123
Comment
None
History
See term history for GO:0140358 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of P-type transmembrane transporter activity (GO:0140358)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
P-type transmembrane transporter activity [is_a relation] is_a  ATPase-coupled transmembrane transporter activity (GO:0042626)
Children of P-type transmembrane transporter activity (GO:0140358)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
P-type ion transporter activity (GO:0015662) [is_a relation] is_a  P-type transmembrane transporter activity
TC
3.A.3
Wikipedia
P-type_ATPase