Term Information

Accession
GO:0110153
Name
RNA NAD-cap (NMN-forming) hydrolase activity
Ontology
molecular_function
Synonyms
None
Alternate IDs
None
Definition
Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H+. Source: GOC:sp, PMID:31101919, RHEA:60876, PMID:25533955
Comment
This reaction specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA.
History
See term history for GO:0110153 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of RNA NAD-cap (NMN-forming) hydrolase activity (GO:0110153)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
RNA NAD-cap (NMN-forming) hydrolase activity [is_a relation] is_a  pyrophosphatase activity (GO:0016462)
RNA NAD-cap (NMN-forming) hydrolase activity [is_a relation] is_a  catalytic activity, acting on RNA (GO:0140098)

This term has no children.

RHEA
60876