Interacting selectivity and noncovalently with a cyclic nucleotide mimicking protein motif that is part of the same protein. The CNBHD is a domain on KCNH channels that creates a binding pocket on the KCNH channel that resembles the cyclic nucleotide- binding domain on other ion channels. It binds to a peptide motif that is part of the same protein rather than a cyclic nucleotide.
Source:
GOC:cvs,
PMID:27025590,
PMID:29567795
Comment
It is unclear if the motif bound by CNBHD is a specific motif or just a beta sheet with the appropriate amino acids.