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mCRD-mediated mRNA stability complex

Term Information

Accession
GO:0106002
Name
mCRD-mediated mRNA stability complex
Ontology
cellular_component
Synonyms
mCRD-poly(A)-bridging complex, major coding region determinant of instability-mediated mRNA stability complex, major coding region instability determinant-mediated mRNA stability complex, major coding region instability determinant-poly(A)-bridging complex, major coding-region determinant of instability - poly(A) tail-bridging complex
Alternate IDs
None
Definition
A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP. Source: PMID:11051545, GOC:bhm
Comment
This complex is related to GO:0070937 CRD-mediated mRNA stability complex but binds the major protein-coding-region determinant of instability (mCRD) domain rather than the CRD. Experimentally it has been shown to act on c-FOS mRNA while GO:0070937 acts on c-MYC mRNA.
History
See term history for GO:0106002 at QuickGO
Subset
None
Feedback
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Parents of mCRD-mediated mRNA stability complex (GO:0106002)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
mCRD-mediated mRNA stability complex [BFO:0000050 relation] BFO:0000050  cytosol (GO:0005829)
mCRD-mediated mRNA stability complex [is_a relation] is_a  protein-containing complex (GO:0032991)

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None.