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transforming growth factor beta complex

Term Information

Accession
GO:0099126
Name
transforming growth factor beta complex
Ontology
cellular_component
Synonyms
TGF-beta complex, TGF-beta dimer, TGFB complex, TGFB dimer, TGFbeta complex, TGFbeta dimer
Alternate IDs
None
Definition
A protein complex acting as ligand of the transforming growth factor beta receptor complex, typically a homodimer of any of the TFGbeta isoforms. The precursor of TGFbeta proteins is cleaved into mature TGFbeta and the latency-associated peptide (LAP), which remains non-covalently linked to mature TGFbeta rendering it inactive. TGFbeta is activated by dimerisation and dissociation of the LAP. Source: PMID:22943793, GOC:bhm
Comment
None
History
See term history for GO:0099126 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of transforming growth factor beta complex (GO:0099126)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
transforming growth factor beta complex [is_a relation] is_a  protein-containing complex (GO:0032991)
transforming growth factor beta complex [BFO:0000050 relation] BFO:0000050  collagen-containing extracellular matrix (GO:0062023)

This term has no children.

None.