Term Information

Accession
GO:0097681
Name
double-strand break repair via alternative nonhomologous end joining
Ontology
biological_process
Synonyms
double-strand break repair via microhomology-mediated end joining, A-NHEJ, MMEJ, alt-NHEJ
Alternate IDs
None
Definition
An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment. Source: GOC:rph, PMID:18584027, PMID:21655080, Wikipedia:Microhomology-mediated_end_joining
Comment
None
History
See term history for GO:0097681 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of double-strand break repair via alternative nonhomologous end joining (GO:0097681)
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double-strand break repair via alternative nonhomologous end joining [is_a relation] is_a  double-strand break repair via nonhomologous end joining (GO:0006303)

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