Catalysis of the reaction: (R)-2-hydroxy-2-phenylacetate + acceptor = phenylglyoxylate + reduced acceptor.
Source:RHEA:43112,
GOC:pr,
PMID:1731758
Comment
In the yeast Rhodotorula graminis, (R)-mandelate dehydrogenase is the first enzyme of the mandelate pathway, and catalyzes the NAD-dependent oxidation of (R)-mandelate to phenylglyoxylate.