Term Information

Accession
GO:0097418
Name
neurofibrillary tangle
Ontology
cellular_component
Synonyms
flame-shaped neurofibrillary tangle, star-shaped neurofibrillary tangle
Alternate IDs
None
Definition
Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star. Source: NIF_Subcellular:sao2409833926, NIF_Subcellular:nlx_subcell_20090202, NIF_Subcellular:nlx_subcell_20090201
Comment
Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).
History
See term history for GO:0097418 at QuickGO
Subset
None
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Parents of neurofibrillary tangle (GO:0097418)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
neurofibrillary tangle [is_a relation] is_a  inclusion body (GO:0016234)

This term has no children.