Term Information

Accession
GO:0097199
Name
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Ontology
molecular_function
Synonyms
cysteine-type endopeptidase activity involved in apoptotic signalling pathway, activator caspase activity, apical caspase activity, initiator caspase activity
Alternate IDs
None
Definition
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway. Source: PMID:11717445, Wikipedia:Caspase, GOC:mtg_apoptosis
Comment
Examples of gene products that may be annotated to this term include CASP2, CASP8, CASP9, and CASP10, also called initiator (or apical, or activator) caspases.
History
See term history for GO:0097199 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:0097199)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
cysteine-type endopeptidase activity involved in apoptotic signaling pathway [is_a relation] is_a  cysteine-type endopeptidase activity involved in apoptotic process (GO:0097153)
cysteine-type endopeptidase activity involved in apoptotic signaling pathway [BFO:0000050 relation] BFO:0000050  apoptotic signaling pathway (GO:0097190)
Children of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:0097199)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:2001268) [RO:0002212 relation] RO:0002212  cysteine-type endopeptidase activity involved in apoptotic signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:2001269) [RO:0002213 relation] RO:0002213  cysteine-type endopeptidase activity involved in apoptotic signaling pathway
regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:2001267) [RO:0002211 relation] RO:0002211  cysteine-type endopeptidase activity involved in apoptotic signaling pathway
None.