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interferon regulatory factor complex

Term Information

Accession
GO:0097071
Name
interferon regulatory factor complex
Ontology
cellular_component
Synonyms
IRF complex
Alternate IDs
None
Definition
A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit. Source: PMID:20043992, GOC:cna
Comment
None
History
See term history for GO:0097071 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of interferon regulatory factor complex (GO:0097071)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
interferon regulatory factor complex [is_a relation] is_a  protein-containing complex (GO:0032991)
Children of interferon regulatory factor complex (GO:0097071)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
interferon regulatory factor 3 complex (GO:0097072) [is_a relation] is_a  interferon regulatory factor complex
interferon regulatory factor 7 complex (GO:0097074) [is_a relation] is_a  interferon regulatory factor complex
interferon regulatory factor 3-interferon regulatory factor 5 complex (GO:0097085) [is_a relation] is_a  interferon regulatory factor complex
interferon regulatory factor 3-interferon regulatory factor 7 complex (GO:0097075) [is_a relation] is_a  interferon regulatory factor complex
interferon regulatory factor 5 complex (GO:0097073) [is_a relation] is_a  interferon regulatory factor complex
None.