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L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating)

Term Information

Accession
GO:0090489
Name
L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating)
Ontology
molecular_function
Synonyms
tryptophan N-monooxygenase activity
Alternate IDs
None
Definition
Catalyzes the multi-step reaction: L-Tryptophan + 2 Oxygen + 2 NADPH + 2 H+ = Indole-3-acetaldehyde oxime + 3 H2O + 2 NADP+ + CO2. The individual reactions are: (1a) L-tryptophan + O2 + NADPH + H+ = N-hydroxy-L-tryptophan + NADP+ + H2O,(1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ = N,N-dihydroxy-L-tryptophan + NADP+ + H2O, and (1c) N,N-dihydroxy-L-tryptophan = (E)-indol-3-ylacetaldoxime + CO2 + H2O. Source: EC:1.14.13.125, KEGG_REACTION:R08160
Comment
None
History
See term history for GO:0090489 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating) (GO:0090489)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating) [is_a relation] is_a  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709)
L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating) [BFO:0000051 relation] BFO:0000051  L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) (GO:0090490)
L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating) [BFO:0000051 relation] BFO:0000051  N,N-Dihydroxy-L-tryptophan decarboxylase activity (GO:0090492)
L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating) [BFO:0000051 relation] BFO:0000051  N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) (GO:0090491)

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