Term Information

Accession
GO:0090201
Name
negative regulation of release of cytochrome c from mitochondria
Ontology
biological_process
Synonyms
None
Alternate IDs
None
Definition
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. Source: GOC:dph, GOC:tb, GOC:BHF, GOC:mtg_apoptosis
Comment
The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and negatively regulate this process.
History
See term history for GO:0090201 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of negative regulation of release of cytochrome c from mitochondria (GO:0090201)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of release of cytochrome c from mitochondria [is_a relation] is_a  negative regulation of mitochondrion organization (GO:0010823)
negative regulation of release of cytochrome c from mitochondria [is_a relation] is_a  regulation of release of cytochrome c from mitochondria (GO:0090199)
negative regulation of release of cytochrome c from mitochondria [is_a relation] is_a  negative regulation of apoptotic signaling pathway (GO:2001234)
negative regulation of release of cytochrome c from mitochondria [RO:0002212 relation] RO:0002212  release of cytochrome c from mitochondria (GO:0001836)

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None.