Term Information

Accession
GO:0086030
Name
adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation
Ontology
biological_process
Synonyms
Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation, adrenergic receptor signaling pathway involved in cardiac muscle relaxation, adrenergic receptor signaling pathway involved in cardiac muscle relaxation via activation of AC, adrenergic receptor-induced cardiac relaxation
Alternate IDs
None
Definition
An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation. Source: GOC:BHF, PMID:10571541, GOC:mtg_cardiac_conduct_nov11
Comment
None
History
See term history for GO:0086030 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation (GO:0086030)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation [BFO:0000050 relation] BFO:0000050  relaxation of cardiac muscle (GO:0055119)
adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation [is_a relation] is_a  adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process (GO:0086023)

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