ubiquitin-dependent protein catabolic process via the N-end rule pathway
Term Information
Accession
GO:0071596
Name
ubiquitin-dependent protein catabolic process via the N-end rule pathway
Ontology
biological_process
Synonyms
ubiquitin-dependent protein breakdown via the N-end rule pathway, ubiquitin-dependent protein catabolism via the N-end rule pathway, ubiquitin-dependent protein degradation via the N-end rule pathway
Alternate IDs
None
Definition
The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation.
Source:PMID:9112437,
GOC:rb,
GOC:mah,
PMID:19246002
Link
to all annotated objects annotated to ubiquitin-dependent protein catabolic process via the N-end rule pathway.
Link
to all direct and indirect annotations
to ubiquitin-dependent protein catabolic process via the N-end rule pathway.
Link
to all direct and indirect annotations download (limited to first 10,000)
for ubiquitin-dependent protein catabolic process via the N-end rule pathway.
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.