Term Information

Accession
GO:0071144
Name
heteromeric SMAD protein complex
Ontology
cellular_component
Synonyms
SMAD1-SMAD4 protein complex, SMAD2-SMAD3-SMAD4 protein complex, SMAD2-SMAD4 protein complex, SMAD3-SMAD4 protein complex
Alternate IDs
GO:0071145, GO:0071146
Definition
A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric. Source: PMID:9389648, PMID:15350224, PMID:11779505, GOC:mah, PMID:9670020, PMID:16322555, GOC:bhm
Comment
None
History
See term history for GO:0071144 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of heteromeric SMAD protein complex (GO:0071144)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
heteromeric SMAD protein complex [is_a relation] is_a  SMAD protein complex (GO:0071141)
heteromeric SMAD protein complex [is_a relation] is_a  RNA polymerase II transcription regulator complex (GO:0090575)

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None.