Term Information

Accession
GO:0070266
Name
necroptotic process
Ontology
biological_process
Synonyms
RIPK1-mediated regulated necrosis, PARP-dependent cell death, activation of necroptosis, activation of necroptosis by extracellular signals, activation of necroptosis in response to extracellular signals, activation of necroptosis of activated-T cells, establishment of necroptosis, establishment of necroptosis of activated-T cells, extracellular signal-induced necroptosis, parthanatos, TNF-induced necroptosis, necroptosis, induction of necroptosis, induction of necroptosis by extracellular signals, induction of necroptosis of activated-T cells, programmed necrosis, programmed necrotic cell death
Alternate IDs
GO:0060554, GO:0060555, GO:0060553
Definition
A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. Source: GOC:dph, GOC:tb, PMID:20823910, GOC:BHF, PMID:21760595, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:21737330, PMID:21876153
Comment
Examples of this are Birc2 and Birc3 (UniProt symbols Q62210 and O08863) in PMID:21052097.
History
See term history for GO:0070266 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of necroptotic process (GO:0070266)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
necroptotic process [is_a relation] is_a  programmed necrotic cell death (GO:0097300)
Children of necroptotic process (GO:0070266)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
execution phase of necroptosis (GO:0097528) [BFO:0000050 relation] BFO:0000050  necroptotic process
necroptotic signaling pathway (GO:0097527) [BFO:0000050 relation] BFO:0000050  necroptotic process
regulation of necroptotic process (GO:0060544) [RO:0002211 relation] RO:0002211  necroptotic process
ripoptosome assembly involved in necroptotic process (GO:1901026) [BFO:0000050 relation] BFO:0000050  necroptotic process
positive regulation of necroptotic process (GO:0060545) [RO:0002213 relation] RO:0002213  necroptotic process
negative regulation of necroptotic process (GO:0060546) [RO:0002212 relation] RO:0002212  necroptotic process
None.