3-methylguanine DNA glycosylase I, DNA glycosidase I activity, deoxyribonucleate 3-methylguanine glycosidase I, alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
Alternate IDs
None
Definition
Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site.
Source:PMID:9224623,
PMID:10872450,
EC:3.2.2.21,
GOC:elh