Term Information

Accession
GO:0051975
Name
lysine biosynthetic process via alpha-aminoadipate and saccharopine
Ontology
biological_process
Synonyms
lysine biosynthesis via aminoadipic acid and saccharopine, lysine biosynthetic process via aminoadipic acid and saccharopine
Alternate IDs
None
Definition
The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine. Source: MetaCyc:LYSINE-AMINOAD-PWY
Comment
None
History
See term history for GO:0051975 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of lysine biosynthetic process via alpha-aminoadipate and saccharopine (GO:0051975)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
lysine biosynthetic process via alpha-aminoadipate and saccharopine [is_a relation] is_a  lysine biosynthetic process via aminoadipic acid (GO:0019878)
Children of lysine biosynthetic process via alpha-aminoadipate and saccharopine (GO:0051975)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine (GO:2001196) [RO:0002213 relation] RO:0002213  lysine biosynthetic process via alpha-aminoadipate and saccharopine
regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine (GO:2001194) [RO:0002211 relation] RO:0002211  lysine biosynthetic process via alpha-aminoadipate and saccharopine
negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine (GO:2001195) [RO:0002212 relation] RO:0002212  lysine biosynthetic process via alpha-aminoadipate and saccharopine