Planteome: Term Details for "ureidoglycolate lyase activity" (GO:0050385)

Term Information

Accession: GO:0050385
Name: ureidoglycolate lyase activity
Ontology: molecular_function
Synonyms: (S)-ureidoglycolate urea-lyase (glyoxylate-forming), (S)-ureidoglycolate urea-lyase activity, ureidoglycolase activity, ureidoglycolatase activity, ureidoglycolate hydrolase activity
Alternate IDs: None
Definition: Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea. Source: RHEA:11304, EC:4.3.2.3
Comment: Take care to annotate to the reaction, not simply by enzyme name. Note that the name "ureidoglycolate hydrolase" (listed as a synonym here) has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC:3.5.3.19 ; GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC:3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC:4.3.2.3 ; GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC:3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name.
History: See term history for GO:0050385 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to ureidoglycolate lyase activity.; Link to all direct and indirect annotations to ureidoglycolate lyase activity.; Link to all direct and indirect annotations download (limited to first 10,000) for ureidoglycolate lyase activity.
Feedback: Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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BFO:0000001 entity
BFO:0000003 occurrent
BFO:0000015 process
GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016829 lyase activity
GO:0016840 carbon-nitrogen lyase activity
GO:0016842 amidine-lyase activity
GO:0050385 ureidoglycolate lyase activity

Parents of ureidoglycolate lyase activity (GO:0050385)

subject	relation	object
ureidoglycolate lyase activity	is_a	amidine-lyase activity (GO:0016842)

This term has no children.

EC: 4.3.2.3
KEGG_REACTION: R00776
MetaCyc: UREIDOGLYCOLATE-LYASE-RXN
RHEA: 11304