Term Information

Accession
GO:0048010
Name
vascular endothelial growth factor receptor signaling pathway
Ontology
biological_process
Synonyms
VEGF receptor signaling pathway, VEGF receptor signalling pathway, VEGFR signaling pathway
Alternate IDs
None
Definition
The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Source: GOC:signaling, GOC:ceb
Comment
In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
History
See term history for GO:0048010 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of vascular endothelial growth factor receptor signaling pathway (GO:0048010)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
vascular endothelial growth factor receptor signaling pathway [is_a relation] is_a  transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)
Children of vascular endothelial growth factor receptor signaling pathway (GO:0048010)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
vascular endothelial growth factor receptor-1 signaling pathway (GO:0036323) [is_a relation] is_a  vascular endothelial growth factor receptor signaling pathway
positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949) [RO:0002213 relation] RO:0002213  vascular endothelial growth factor receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment (GO:0060851) [is_a relation] is_a  vascular endothelial growth factor receptor signaling pathway
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway (GO:0038033) [is_a relation] is_a  vascular endothelial growth factor receptor signaling pathway
negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948) [RO:0002212 relation] RO:0002212  vascular endothelial growth factor receptor signaling pathway
vascular endothelial growth factor receptor-3 signaling pathway (GO:0036325) [is_a relation] is_a  vascular endothelial growth factor receptor signaling pathway
vascular endothelial growth factor receptor-2 signaling pathway (GO:0036324) [is_a relation] is_a  vascular endothelial growth factor receptor signaling pathway
regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947) [RO:0002211 relation] RO:0002211  vascular endothelial growth factor receptor signaling pathway
None.