maintenance of DNA methylation at imprinted genes, protection of DNA demethylation of female pronucleus, protection of DNA methylation in female pronucleus
Alternate IDs
None
Definition
The global programming of epigenetic modifications in the female pronucleus of the newly fertilized zygote. The maternal genome is protected from global DNA demethylation before the first division of the zygote, and instead undergoes passive, replication-dependent demethylation during early embryogenesis, arising from inhibition of the DNA maintenance methyltransferase Dnmt1.
Source:
GOC:sp,
PMID:22868271