A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms.
Source:PMID:10428850,
PMID:12176339,
PMID:11406413,
GOC:mtg_apoptosis,
PMID:15189137