Planteome: Term Details for "PKR-mediated signaling" (GO:0039585)

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Term Information

Accession: GO:0039585
Name: PKR-mediated signaling
Ontology: biological_process
Synonyms: EIF2AK2 signal transduction, EIF2AK2/PRK signaling, PKR signal transduction, PKR signaling pathway, signaling through PKR
Alternate IDs: None
Definition: A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK2), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation. Source: PMID:21204021, PMID:9843495, PMID:22102852, PMID:27629041, VZ:1576
Comment: None
History: See term history for GO:0039585 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to PKR-mediated signaling.; Link to all direct and indirect annotations to PKR-mediated signaling.; Link to all direct and indirect annotations download (limited to first 10,000) for PKR-mediated signaling.
Feedback: Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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BFO:0000001 entity
BFO:0000003 occurrent
GO:0008150 biological_process
GO:0065007 biological regulation
BFO:0000015 process
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0110165 cellular anatomical entity
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0006950 response to stress
GO:0023052 signaling
GO:0033554 cellular response to stress
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0140467 integrated stress response signaling
GO:0035556 intracellular signal transduction
GO:0039585 PKR-mediated signaling

Parents of PKR-mediated signaling (GO:0039585)

subject	relation	object
PKR-mediated signaling	is_a	intracellular signal transduction (GO:0035556)
PKR-mediated signaling	is_a	integrated stress response signaling (GO:0140467)

This term has no children.

PKR-mediated signaling

Term Information

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Parents of PKR-mediated signaling (GO:0039585)

None.